Onset and spread of dyskinesias and motor symptoms in Parkinson's disease
Identifieur interne : 002519 ( Main/Corpus ); précédent : 002518; suivant : 002520Onset and spread of dyskinesias and motor symptoms in Parkinson's disease
Auteurs : Giovanni Fabbrini ; Giovanni Defazio ; Carlo Colosimo ; Antonio Suppa ; Maria Bloise ; Alfredo BerardelliSource :
- Movement Disorders [ 0885-3185 ] ; 2009-10-30.
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Abstract
We retrospectively investigated in consecutive Parkinson's disease (PD) outpatients the relationship between the body region in which LID first appeared and the body region where Parkinsonian motor symptoms started. We also studied the spread of LID and motor symptoms to other body parts during the progression of PD. Of the 307 PD patients investigated, 99 with LID were enrolled in the study. In these 99 patients, LID started unilaterally in the limbs in 44, bilaterally in the limbs in 26, and in craniocervical region in 29, whereas motor symptoms invariably started in the limbs. LID and motor symptoms started in the same body region in less than half of the patients studied. Of the 99 patients studied, 69 had LID spread to at least another body region during the course of their disease. In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22703
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ISTEX:BB4F3066149608A09947959E0C27693D79F5B9B4Le document en format XML
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We also studied the spread of LID and motor symptoms to other body parts during the progression of PD. Of the 307 PD patients investigated, 99 with LID were enrolled in the study. In these 99 patients, LID started unilaterally in the limbs in 44, bilaterally in the limbs in 26, and in craniocervical region in 29, whereas motor symptoms invariably started in the limbs. LID and motor symptoms started in the same body region in less than half of the patients studied. Of the 99 patients studied, 69 had LID spread to at least another body region during the course of their disease. In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Giovanni Fabbrini MD</name><affiliations><json:string>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Defazio MD</name><affiliations><json:string>Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy</json:string></affiliations></json:item><json:item><name>Carlo Colosimo MD</name><affiliations><json:string>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Antonio Suppa MD</name><affiliations><json:string>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Maria Bloise MD</name><affiliations><json:string>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Alfredo Berardelli MD</name><affiliations><json:string>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dyskinesias</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>L‐dopa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item></subject><articleId><json:string>MDS22703</json:string></articleId><language><json:string>eng</json:string></language><abstract>We retrospectively investigated in consecutive Parkinson's disease (PD) outpatients the relationship between the body region in which LID first appeared and the body region where Parkinsonian motor symptoms started. 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We also studied the spread of LID and motor symptoms to other body parts during the progression of PD. Of the 307 PD patients investigated, 99 with LID were enrolled in the study. In these 99 patients, LID started unilaterally in the limbs in 44, bilaterally in the limbs in 26, and in craniocervical region in 29, whereas motor symptoms invariably started in the limbs. LID and motor symptoms started in the same body region in less than half of the patients studied. Of the 99 patients studied, 69 had LID spread to at least another body region during the course of their disease. In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson disease</term></item><item><term>dyskinesias</term></item><item><term>L‐dopa</term></item><item><term>basal ganglia</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-03-04">Received</change><change when="2009-06-20">Registration</change><change when="2009-10-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/BB4F3066149608A09947959E0C27693D79F5B9B4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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We also studied the spread of LID and motor symptoms to other body parts during the progression of PD. Of the 307 PD patients investigated, 99 with LID were enrolled in the study. In these 99 patients, LID started unilaterally in the limbs in 44, bilaterally in the limbs in 26, and in craniocervical region in 29, whereas motor symptoms invariably started in the limbs. LID and motor symptoms started in the same body region in less than half of the patients studied. Of the 99 patients studied, 69 had LID spread to at least another body region during the course of their disease. In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: There are no funding sources and potential conflicts of interest from none of the authors who relate to the research covered in this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Onset and spread of dyskinesias and motor symptoms in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Onset and Spread of Dyskinesias</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Onset and spread of dyskinesias and motor symptoms in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Fabbrini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Defazio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Colosimo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Suppa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria</namePart><namePart type="family">Bloise</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfredo</namePart><namePart type="family">Berardelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy</affiliation><description>Correspondence: Department of Neurological Sciences, Neuromed Institute, Sapienza University of Rome, Viale dell'Università 30, Rome 00185, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-10-30</dateIssued><dateCaptured encoding="w3cdtf">2009-03-04</dateCaptured><dateValid encoding="w3cdtf">2009-06-20</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">38</extent><extent unit="words">4363</extent></physicalDescription><abstract lang="en">We retrospectively investigated in consecutive Parkinson's disease (PD) outpatients the relationship between the body region in which LID first appeared and the body region where Parkinsonian motor symptoms started. We also studied the spread of LID and motor symptoms to other body parts during the progression of PD. Of the 307 PD patients investigated, 99 with LID were enrolled in the study. In these 99 patients, LID started unilaterally in the limbs in 44, bilaterally in the limbs in 26, and in craniocervical region in 29, whereas motor symptoms invariably started in the limbs. LID and motor symptoms started in the same body region in less than half of the patients studied. Of the 99 patients studied, 69 had LID spread to at least another body region during the course of their disease. In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: There are no funding sources and potential conflicts of interest from none of the authors who relate to the research covered in this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson disease</topic><topic>dyskinesias</topic><topic>L‐dopa</topic><topic>basal ganglia</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2091</start><end>2096</end><total>6</total></extent></part></relatedItem><identifier type="istex">BB4F3066149608A09947959E0C27693D79F5B9B4</identifier><identifier type="DOI">10.1002/mds.22703</identifier><identifier type="ArticleID">MDS22703</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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